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How To: Predict Effects

BioMCP can request functional-impact predictions through the variant predict section.

Requirements

  • Set ALPHAGENOME_API_KEY.
  • Prefer a resolvable genomic variant identifier.

Example

export ALPHAGENOME_API_KEY="..."
biomcp get variant "chr7:g.140453136A>T" predict

Alternate input

biomcp get variant "BRAF V600E" predict

Validation behavior

BioMCP validates identifiers and dates before expensive network work. If a variant cannot be resolved to a supported prediction path, an explicit error or warning is returned.

Practical guidance

  • Use prediction output as one signal, not a final interpretation.
  • Pair predictions with variant annotations and literature context.