OpenTargets¶
OpenTargets matters when you need ranked target-disease context instead of a flat list of associations. It is especially useful for deciding whether a gene looks disease-relevant, whether a target appears tractable, and how much supporting signal exists behind a drug or disease pivot.
In BioMCP, OpenTargets powers the gene druggability section and contributes ranked evidence to get gene <symbol> diseases and get disease <id> genes. Those surfaces remain mixed-source, but OpenTargets scores are the shared signal behind disease ranking, prevalence context, and parts of the drug target and indication workflow.
What BioMCP exposes¶
| Command | What BioMCP gets from this source | Integration note |
|---|---|---|
get gene <symbol> diseases |
Ranked disease associations for a gene | OpenTargets scores anchor the disease ranking |
get gene <symbol> druggability |
Tractability, safety, and targetability context | Combined with DGIdb interactions in one gene section |
get drug <name> targets |
Drug-target context for known therapies | Mixed with ChEMBL target evidence |
get drug <name> indications |
Disease and indication context for drugs | Mixed with ChEMBL indication enrichment |
get disease <id> genes |
Ranked associated genes for a disease | Monarch-backed rows can be augmented with OpenTargets scores |
get disease <id> prevalence |
Prevalence-like evidence and disease burden context | OpenTargets-backed disease section |
Example commands¶
Returns disease associations for BRAF with OpenTargets-backed ranking context.
Returns a druggability section with tractability and safety signals.
Returns disease-associated genes with OpenTargets score summaries when available.
Returns prevalence-like evidence for the normalized disease record.
Returns a drug targets section where OpenTargets joins ChEMBL target context.
API access¶
No BioMCP API key required.
Official source¶
OpenTargets is the official target-disease platform behind BioMCP's OpenTargets-backed ranking and tractability signals.